A randomised, crossover, clinical study to assess nicotine pharmacokinetics and subjective effects of the BIDI^® stick ENDS compared with combustible cigarettes and a comparator ENDS in adult smokers.

ABSTRACT:

Background

Nicotine pharmacokinetic assessments of electronic nicotine delivery systems (ENDS) are crucial to understand their ability to provide an alternative to cigarette smoking. Subjective effects data also strongly contribute to this understanding. The BIDI^® Stick is a disposable ENDS product which contains 59 mg/ml nicotine benzoate salt and various flavours.

Methods

In this study, we assessed nicotine pharmacokinetics and subjective effects of 6 flavour variants of BIDI^® Stick ENDS in adult smokers, compared to cigarettes and a comparator ENDS product. During each of eight study visits, 18 volunteer smoker subjects randomly used one of either their usual brand (UB) of cigarette, a BIDI^® Stick ENDS, or a comparator ENDS (JUUL 59 mg/ml

SUBMITTER: Fearon IM 

PROVIDER: S-EPMC9160848 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature