Effects of colchicine use on ischemic and hemorrhagic stroke risk in diabetic patients with and without gout.

ABSTRACT: This study aimed to determine the effect of colchicine use on the risk of stroke among patients with diabetes mellitus (DM). We retrospectively enrolled patients with DM between 2000 and 2013 from the Longitudinal Health Insurance Database and divided them into a colchicine cohort (n = 8761) and noncolchicine cohort (n = 8761) by using propensity score matching (PSM). The event of interest was a stroke, including ischemic stroke and hemorrhagic stroke. The incidence of stroke was analyzed using multivariate Cox proportional hazards models between the colchicine cohort and the comparison cohort after adjustment for several confounding factors. The subdistribution hazard model was also performed for examination of the competing risk. The colchicine cohort had a significantly lower incidence

SUBMITTER: Yeh JJ 

PROVIDER: S-EPMC9160857 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature