The association between the inflammatory response following surgery and post-operative delirium in older oncological patients: a prospective cohort study.

ABSTRACT:

Introduction

Post-operative delirium (POD) is associated with increased morbidity and mortality rates in older patients. Neuroinflammation, the activation of the intrinsic immune system of the brain, seems to be one of the mechanisms behind the development of POD. The aim of this study was to explore the association between the perioperative inflammatory response and the development of POD in a cohort of older oncological patients in need for surgery.

Methods

In this prospective cohort study, patients 65 years and older in need for oncologic surgery were included. Inflammatory markers C-reactive protein (CRP), interleukin-1 beta (IL-1β), IL-6, IL10 and Neutrophil gelatinase-associated lipocalin (NGAL) were measured in plasma samples pre- and post-operatively. Delirium Observ

SUBMITTER: Brattinga B 

PROVIDER: S-EPMC9160877 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature