Factors associated with failure of high-flow nasal cannula oxygen therapy in patients with severe COVID-19: a retrospective case series.

ABSTRACT:

Objective

To identify factors associated with high-flow nasal cannula (HFNC) therapy failure in patients with severe COVID-19.

Methods

We retrospectively examined clinical and laboratory data upon admission, treatments, and outcomes of patients with severe COVID-19. Sequential Organ Failure Assessment (SOFA) scores were also calculated.

Results

Of 54 patients with severe COVID-19, HFNC therapy was successful in 28 (51.9%) and unsuccessful in 26 (48.1%). HFNC therapy failure was more common in patients aged ≥60 years and in men. Compared with patients with successful HFNC therapy, patients with HFNC therapy failure had higher percentages of fatigue, anorexia, and cardiovascular disease; a longer time from symptom onset to diagnosis; higher SOFA scores; a higher body te

SUBMITTER: Ma XH 

PROVIDER: S-EPMC9160912 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature