Methyl Metabolism and the Clock: An Ancient Story With New Perspectives.

ABSTRACT: Methylation, that is, the transfer or synthesis of a -CH₃ group onto a target molecule, is a pervasive biochemical modification found in organisms from bacteria to humans. In mammals, a complex metabolic pathway powered by the essential nutrients vitamin B9 and B12, methionine and choline, synthesizes S-adenosylmethionine, the methyl donor in the methylation of nucleic acids, proteins, fatty acids, and small molecules by over 200 substrate-specific methyltransferases described so far in humans. Methylations not only play a key role in scenarios for the origin and evolution of life, but they remain essential for the development and physiology of organisms alive today, and methylation deficiencies contribute to the etiology of many pathologies. The methylation of histones a

SUBMITTER: Fustin JM 

PROVIDER: S-EPMC9160962 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature