Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19.

ABSTRACT: The worldwide COVID-19 pandemic has claimed millions of lives and has had a profound effect on global life. Understanding the body's immune response to SARS-CoV-2 infection is crucial in improving patient management and prognosis. In this study we compared influenza and SARS-CoV-2 infected patient cohorts to identify distinct blood transcript abundances and cellular composition to better understand the natural immune response associated with COVID-19, compared to another viral infection being influenza, and identify a prognostic signature of COVID-19 patient outcome. Clinical characteristics and peripheral blood were acquired upon hospital admission from two well characterised cohorts, a cohort of 88 patients infected with influenza and a cohort of 80 patients infected with SARS-CoV-2 duri

SUBMITTER: Legebeke J 

PROVIDER: S-EPMC9160963 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature