Identification of Clinical Phenotypes in Septic Patients Presenting With Hypotension or Elevated Lactate.

ABSTRACT:

Introduction

Targeted therapies for sepsis have failed to show benefit due to high variability among subjects. We sought to demonstrate different phenotypes of septic shock based solely on clinical features and show that these relate to outcome.

Methods

A retrospective analysis was performed of a 1,023-subject cohort with early septic shock from the ProCESS trial. Twenty-three clinical variables at baseline were analyzed using hierarchical clustering, with consensus clustering used to identify and validate the ideal number of clusters in a derivation cohort of 642 subjects from 20 hospitals. Clusters were visualized using heatmaps over 0, 6, 24, and 72 h. Clinical outcomes were 14-day all-cause mortality and organ failure pattern. Cluster robustness was confirmed in a valida

SUBMITTER: Aldewereld ZT 

PROVIDER: S-EPMC9160971 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature