Emergence of bla _{NDM- 1}-Carrying Aeromonas caviae K433 Isolated From Patient With Community-Acquired Pneumonia.

ABSTRACT: To demonstrate the detailed genetic characteristics of a bla _NDM-1-carrying multidrug-resistant Aeromonas caviae strain, the complete genome of the A. caviae strain K433 was sequenced by Illumina HiSeq and Oxford nanopore platforms, and mobile genetic elements associated with antibiotic resistance genes were analyzed by a series of bioinformatics methods. A. caviae K433 which was determined to produce class B carbapenemase, was resistant to most antibiotics tested except amikacin. The genome of K433 consisted of a chromosome cK433 (6,482-kb length) and two plasmids: pK433-qnrS (7.212-kb length) and pK433-NDM (200.855-kb length), the last being the first investigated bla _NDM-carrying plasmid from Aeromonas spp. By comparison of

SUBMITTER: Luo X 

PROVIDER: S-EPMC9161076 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature