Mapping the O-GlcNAc Modified Proteome: Applications for Health and Disease.
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ABSTRACT:
SUBMITTER: Burt RA
PROVIDER: S-EPMC9161079 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Mapping the O-GlcNAc Modified Proteome: Applications for Health and Disease.
Burt Rajan A RA Alghusen Ibtihal M IM John Ephrame Sophiya S Villar Maria T MT Artigues Antonio A Slawson Chad C
Frontiers in molecular biosciences 20220519
O-GlcNAc is a pleotropic, enigmatic post-translational modification (PTM). This PTM modifies thousands of proteins differentially across tissue types and regulates diverse cellular signaling processes. O-GlcNAc is implicated in numerous diseases, and the advent of O-GlcNAc perturbation as a novel class of therapeutic underscores the importance of identifying and quantifying the O-GlcNAc modified proteome. Here, we review recent advances in mass spectrometry-based proteomics that will be critical ...[more]
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