Longitudinal Dynamics of Cellular Responses in Recovered COVID-19 Patients.

ABSTRACT: Safe and effective vaccines and therapeutics based on the understanding of antiviral immunity are urgently needed to end the COVID-19 pandemic. However, the understanding of these immune responses, especially cellular immune responses to SARS-CoV-2 infection, is limited. Here, we conducted a cohort study of COVID-19 patients who were followed and had blood collected to characterize the longitudinal dynamics of their cellular immune responses. Compared with healthy controls, the percentage of activation of SARS-CoV-2 S/N-specific T cells in recovered patients was significantly higher. And the activation percentage of S/N-specific CD8⁺ T cells in recovered patients was significantly higher than that of CD4⁺ T cells. Notably, SARS-CoV-2 specific T-cell responses were str

SUBMITTER: Cheng ML 

PROVIDER: S-EPMC9161166 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature