Cyclooxygenase-Derived Prostaglandin E₂ Drives IL-1-Independent Mycobacterium bovis Bacille Calmette-Guerin-Triggered Skin Dendritic Cell Migration to Draining Lymph Node.

ABSTRACT: Inoculation of Mycobacterium bovis Bacille Calmette-Guérin (BCG) in the skin mobilizes local dendritic cells (DC) to the draining lymph node (dLN) in a process that remains incompletely understood. In this study, a mouse model of BCG skin infection was used to investigate mechanisms of skin DC migration to dLNs. We found enhanced transcription of cyclooxygenase (COX)-2 and production of COX-derived PGE₂ early after BCG infection in skin. Animals treated with antagonists for COX or the PGE₂ receptors EP2 and EP4 displayed a marked reduction in the entry of skin DCs and BCG to dLNs, uncovering an important contribution of COX-derived PGE₂ in this migration process. In addition, live BCG bacilli were needed to invoke DC migration through this COX-PGE

SUBMITTER: Krmeska V 

PROVIDER: S-EPMC9161203 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature