Cytotoxicity Assessment of Surface-Modified Magnesium Hydroxide Nanoparticles.

ABSTRACT: Magnesium-based nanoparticles have shown promise in regenerative therapies in orthopedics and the cardiovascular system. Here, we set out to assess the influence of differently functionalized Mg nanoparticles on the cellular players of wound healing, the first step in the process of tissue regeneration. First, we thoroughly addressed the physicochemical characteristics of magnesium hydroxide nanoparticles, which exhibited low colloidal stability and strong aggregation in cell culture media. To address this matter, magnesium hydroxide nanoparticles underwent surface functionalization by 3-aminopropyltriethoxysilane (APTES), resulting in excellent dispersible properties in ethanol and improved colloidal stability in physiological media. The latter was determined as a concentration- and time-

SUBMITTER: Echeverry-Rendon M 

PROVIDER: S-EPMC9161253 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature