Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair.

ABSTRACT: Kidneys have the capacity for intrinsic repair, preserving kidney architecture with return to a basal state after tubular injury. When injury is overwhelming or repetitive, however, that capacity is exceeded and incomplete repair results in fibrotic tissue replacing normal kidney parenchyma. Loss of nephrons correlates with reduced kidney function, which defines chronic kidney disease (CKD) and confers substantial morbidity and mortality to the worldwide population. Despite the identification of pathways involved in intrinsic repair, limited treatments for CKD exist, partly because of the limited throughput and predictivity of animal studies. Here, we showed that kidney organoids can model the transition from intrinsic to incomplete repair. Single-nuclear RNA sequencing of kidney organoids

SUBMITTER: Gupta N 

PROVIDER: S-EPMC9161367 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature