Quantum Chemical Study on Mefenamic Acid Polymorphic Forms.

ABSTRACT: Three polymorphic structures of mefenamic acid, which is a very popular drug, have been studied using quantum chemical methods. It has been shown that the centrosymmetric dimer formed due to two O-H···O hydrogen bonds is a complex building unit in all of the polymorphic structures under study. On the basis of an analysis of the pairwise interaction energies between molecules, the polymorphic forms I and II are classified as columnar-layered while the polymorphic form III has a columnar structure. The stabilities of the three polymorphic forms of mefenamic acid under ambient conditions (I > II > III) correlate with the degree of anisotropy of the interaction energies between columns (primary basic structural motifs) formed due to stacking interactio

SUBMITTER: Shishkina SV 

PROVIDER: S-EPMC9161385 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature