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Nintedanib-Containing Dual Conjugates Targeting αVβ6 Integrin and Tyrosine Kinase Receptors as Potential Antifibrotic Agents.

ABSTRACT: αVβ6 Integrin plays a fundamental role in the activation of transforming growth factor-β (TGF-β), the major profibrotic mediator; for this reason, αVβ6 ligands have recently been forwarded to clinical phases for the therapy of fibrotic diseases. Herein, we report the synthesis and in vitro biological evaluation as antifibrotic agents of three new covalent conjugates, constituted by c(AmpLRGDL), an αVβ6 integrin-recognizing small cyclopeptide, and nintedanib, a tyrosine kinase inhibitor approved for idiopathic pulmonary fibrosis (IPF) treatment. One of these conjugates recapitulates optimal in vitro antifibrotic properties of the two active units. The integrin ligand portion within the conjugate plays a role in inhibiting profibrotic stimuli, potentiating the nintedanib effect and favoring the selective uptake of the conjugate in cells overexpressing αVβ6 integrin. These results may open a new perspective on the development of dual conjugates in the targeted therapy of IPF.

SUBMITTER: Bugatti K 

PROVIDER: S-EPMC9161413 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Nintedanib-Containing Dual Conjugates Targeting α<sub>V</sub>β<sub>6</sub> Integrin and Tyrosine Kinase Receptors as Potential Antifibrotic Agents.

Bugatti Kelly K   Andreucci Elena E   Monaco Noemi N   Battistini Lucia L   Peppicelli Silvia S   Ruzzolini Jessica J   Curti Claudio C   Zanardi Franca F   Bianchini Francesca F   Sartori Andrea A  

ACS omega 20220517 21

α<sub>V</sub>β<sub>6</sub> Integrin plays a fundamental role in the activation of transforming growth factor-β (TGF-β), the major profibrotic mediator; for this reason, α<sub>V</sub>β<sub>6</sub> ligands have recently been forwarded to clinical phases for the therapy of fibrotic diseases. Herein, we report the synthesis and <i>in vitro</i> biological evaluation as antifibrotic agents of three new covalent conjugates, constituted by <i>c</i>(AmpLRGDL), an α<sub>V</sub>β<sub>6</sub> integrin-recog  ...[more]

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