In-Membrane Nanostructuring of Cationic Amphiphiles Affects Their Antimicrobial Efficacy and Cytotoxicity: A Comparison Study between a De Novo Antimicrobial Lipopeptide and Traditional Biocides.

ABSTRACT: Cationic biocides have been widely used as active ingredients in personal care and healthcare products for infection control and wound treatment for a long time, but there are concerns over their cytotoxicity and antimicrobial resistance. Designed lipopeptides are potential candidates for alleviating these issues because of their mildness to mammalian host cells and their high efficacy against pathogenic microbial membranes. In this study, antimicrobial and cytotoxic properties of a de novo designed lipopeptide, CH₃(CH₂)₁₂CO-Lys-Lys-Gly-Gly-Ile-Ile-NH₂ (C₁₄KKGGII), were assessed against that of two traditional cationic biocides C_nTAB (n = 12 and 14), with different critical aggregation concentrations (CACs). C<

SUBMITTER: Fa K 

PROVIDER: S-EPMC9161444 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature