Inherent constraints on a polyfunctional tissue lead to a reproduction-immunity tradeoff.

ABSTRACT:

Background

Single tissues can have multiple functions, which can result in constraints, impaired function, and tradeoffs. The insect fat body performs remarkably diverse functions including metabolic control, reproductive provisioning, and systemic immune responses. How polyfunctional tissues simultaneously execute multiple distinct physiological functions is generally unknown. Immunity and reproduction are observed to trade off in many organisms but the mechanistic basis for this tradeoff is also typically not known. Here we investigate constraints and trade-offs in the polyfunctional insect fat body.

Results

Using single-nucleus sequencing, we determined that the Drosophila melanogaster fat body executes diverse basal functions with heterogenous cellular subpopulations. Th

SUBMITTER: Gupta V 

PROVIDER: S-EPMC9161490 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature