1,25-Dihydroxyvitamin D₃ and dietary vitamin D reduce inflammation in mice lacking intestinal epithelial cell Rab11a.

ABSTRACT: A number of studies have examined the effects of 1,25-dihydroxyvitamin D₃ (1,25(OH)₂ D₃ ) on intestinal inflammation driven by immune cells, while little information is currently available about its impact on inflammation caused by intestinal epithelial cell (IEC) defects. Mice lacking IEC-specific Rab11a a recycling endosome small GTPase resulted in increased epithelial cell production of inflammatory cytokines, notably IL-6 and early onset of enteritis. To determine whether vitamin D supplementation may benefit hosts with epithelial cell-originated mucosal inflammation, we evaluated in vivo effects of injected 1,25(OH)₂ D₃ or dietary supplement of a high dose of vitamin D on the gut phenotypes of IEC-specific Rab11a knockout mice (Ra

SUBMITTER: Goswami S 

PROVIDER: S-EPMC9161497 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature