Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster.

ABSTRACT:

Background

The heme group constitutes a major functional form of iron, which plays vital roles in various biological processes including oxygen transport and mitochondrial respiration. Heme is an essential nutrient, but its pro-oxidant nature may have toxic cellular effects if present at high levels, and its synthesis is therefore tightly regulated. Deficiency and excess of heme both lead to pathological processes; however, our current understanding of metazoan heme transport is largely limited to work in mammals and the worm Caenorhabditis elegans, while functional analyses of heme transport in the genetically amenable Drosophila melanogaster and other arthropods have not been explored.

Results

We implemented a functional screening in Schneider 2 (S2) cells to identify puta

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9161523 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature