Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies.

ABSTRACT:

Background and objectives

Cancer morbidity and mortality rates remain high, and thus, at present, considerable efforts are focused on finding drugs with higher sensitivity against tumor cells and fewer side effects. Disulfiram (DSF), as an anti-alcoholic drug, kills the cancer cells by inducing apoptosis. Several preclinical and clinical studies have examined the potential of repurposing DSF as an anticancer treatment. This systematic review aimed to assess evidence regarding the antineoplastic activity of DSF in in vitro and in vivo models, as well as in humans.

Methods

Two authors independently conducted this systematic review of English and Chinese articles from the PubMed, Embase, and the Cochrane Library databases up to July 2019. Eligible in vitro studies needed to inc

SUBMITTER: Wang L 

PROVIDER: S-EPMC9161604 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature