Adiposity and grip strength: a Mendelian randomisation study in UK Biobank.

ABSTRACT:

Background

Muscle weakness, which increases in prevalence with age, is a major public health concern. Grip strength is commonly used to identify weakness and an improved understanding of its determinants is required. We aimed to investigate if total and central adiposity are causally associated with grip strength.

Methods

Up to 470,786 UK Biobank participants, aged 38-73 years, with baseline data on four adiposity indicators (body mass index (BMI), body fat percentage (BF%), waist circumference (WC) and waist-hip-ratio (WHR)) and maximum grip strength were included. We examined sex-specific associations between each adiposity indicator and grip strength. We explored whether associations varied by age, by examining age-stratified associations (< 50 years, 50-59 years, 60-64 y

SUBMITTER: Pinto Pereira SM 

PROVIDER: S-EPMC9161610 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature