L-Type Cav 1.2 Calcium Channel-α-1C Regulates Response to Rituximab in Diffuse Large B-Cell Lymphoma.

ABSTRACT:

Purpose

One third of patients with diffuse large B-cell lymphoma (DLBCL) succumb to the disease partly due to rituximab resistance. Rituximab-induced calcium flux is an important inducer of apoptotic cell death, and we investigated the potential role of calcium channels in rituximab resistance.

Experimental design

The distinctive expression of calcium channel members was compared between patients sensitive and resistant to rituximab, cyclophosphamide, vincristine, doxorubicin, prednisone (RCHOP) regimen. The observation was further validated through mechanistic in vitro and in vivo studies using cell lines and patient-derived xenograft mouse models.

Results

A significant inverse correlation was observed between CACNA1C expression and RCHOP resista

SUBMITTER: Zhang JY 

PROVIDER: S-EPMC9161643 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature