A prospective evaluation of hippocampal radiation dose volume effects and memory deficits following cranial irradiation.

ABSTRACT:

Background and purpose

To prospectively evaluate hippocampal radiation dose volume effects and memory decline following cranial irradiation.

Material and methods

Effects of hippocampal radiation over a wide range of doses were investigated by combining data from three prospective studies. In one, adults with small cell lung cancer received hippocampal-avoidance prophylactic cranial irradiation. In the other two, adults with glioblastoma multiforme received neural progenitor cell sparing radiation or no sparing with extra dose delivered to subventricular zone. Memory was measured by the Hopkins Verbal Learning Test-Revised Delayed Recall (HVLT-R DR) at 6 months after radiation. Dose-volume histograms were generated and dose-response data were fitted to a nonlinear model.

R

SUBMITTER: Ma TM 

PROVIDER: S-EPMC9161646 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature