Prognostic factors related to overall survival in adolescent and young adults with medulloblastoma: A systematic review.

ABSTRACT:

Background

Medulloblastoma is a rare diagnosis among adolescents and young adults (AYA). Though prognostic factors and treatment are well characterized among children with medulloblastoma, equivalent data for AYA are sparse. We conducted a systematic review to identify predictors of survival among AYA with medulloblastoma.

Methods

We searched for primary studies of AYA (age 15-39 at diagnosis) with medulloblastoma in high-income countries within OVID MEDLINE, EMBASE, and EBM Reviews-Cochrane library databases from inception to August 2020. Patient demographics, primary outcomes, and univariate and multivariable data on all prognostic factors were collected from included studies. Prognosticators were characterized as patient, disease, or treatment-related.

Results

We i

SUBMITTER: Yan H 

PROVIDER: S-EPMC9161716 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature