Immunosuppressant Medication Use in Patients with Kidney Allograft Failure: A Prospective Multicenter Canadian Cohort Study.

ABSTRACT:

Background

Patients with kidney transplant failure have a high risk of hospitalization and death due to infection. The optimal use of immunosuppressants after transplant failure remains uncertain and clinical practice varies widely.

Methods

This prospective cohort study enrolled patients within 21 days of starting dialysis after transplant failure in 16 Canadian centers. Immunosuppressant medication use, death, hospitalized infection, rejection of the failed allograft, and anti-HLA panel reactive antibodies were determined at 1, 3, 6, and 12 months and and then twice yearly until death, repeat transplantation, or loss to follow-up.

Results

The 269 study patients were followed for a median of 558 days. There were 33 deaths, 143 patients hospitalized for infection, and

SUBMITTER: Knoll G 

PROVIDER: S-EPMC9161795 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature