Intestinal Bacterial Translocation Contributes to Diabetic Kidney Disease.

ABSTRACT:

Background

In recent years, many studies have focused on the intestinal environment to elucidate pathogenesis of various diseases, including kidney diseases. Impairment of the intestinal barrier function, the "leaky gut," reportedly contributes to pathologic processes in some disorders. Mitochondrial antiviral signaling protein (MAVS), a component of innate immunity, maintains intestinal integrity. The effects of disrupted intestinal homeostasis associated with MAVS signaling in diabetic kidney disease remains unclear.

Methods

To evaluate the contribution of intestinal barrier impairment to kidney injury under diabetic conditions, we induced diabetic kidney disease in wild-type and MAVS knockout mice through unilateral nephrectomy and streptozotocin treatment. We then assess

SUBMITTER: Linh HT 

PROVIDER: S-EPMC9161796 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature