High expression of H2A histone family member Y promotes the proliferation and autophagy of hepatocellular carcinoma cells.

ABSTRACT: Hepatocellular carcinoma is a common malignant tumor and the third most common cause of cancer-related deaths. In this study, we selected H2AFY as a potential oncogene from three online databases, and verified differential expression between normal and liver cancer tissues. Moreover, H2AFY expression was significantly correlated with the clinical characteristics and the survival of liver cancer patients. H2AFY expression was correlated with poor prognosis of liver cancer patients. H2AFY expression was also significantly higher in liver cancer cells. Knockdown and overexpression of H2AFY in liver cancer cells showed that H2AFY promoted the proliferation and clone formation of liver cancer cells but had no significant effects on the migration and invasion ability of liver cancer cells. Weste

SUBMITTER: Lei J 

PROVIDER: S-EPMC9161916 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature