Effects of acute and repeated administration of the selective M₄ PAM VU0152099 on cocaine versus food choice in male rats.

ABSTRACT: Ligands that stimulate muscarinic acetylcholine receptors 1 and 4 (M₁ , M₄ ) have shown promising effects as putative pharmacotherapy for cocaine use disorder in rodent assays. We have previously shown reductions in cocaine effects with acute M₄ stimulation, as well as long-lasting, delayed reductions in cocaine taking and cocaine seeking with combined M₁ /M₄ receptor stimulation or with M₁ stimulation alone. M₄ stimulation opposes dopaminergic signalling acutely, but direct dopamine receptor antagonists have proved unhelpful in managing cocaine use disorder because they lose efficacy with long-term administration. It is therefore critical to determine whether M₄ approaches themselves can remain effecti

SUBMITTER: Thomsen M 

PROVIDER: S-EPMC9162150 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature