Recent Progress in Recombinant Influenza Vaccine Development Toward Heterosubtypic Immune Response.

ABSTRACT: Flu, a viral infection caused by the influenza virus, is still a global public health concern with potential to cause seasonal epidemics and pandemics. Vaccination is considered the most effective protective strategy against the infection. However, given the high plasticity of the virus and the suboptimal immunogenicity of existing influenza vaccines, scientists are moving toward the development of universal vaccines. An important property of universal vaccines is their ability to induce heterosubtypic immunity, i.e., a wide immune response coverage toward different influenza subtypes. With the increasing number of studies and mounting evidence on the safety and efficacy of recombinant influenza vaccines (RIVs), they have been proposed as promising platforms for the development of universa

SUBMITTER: Carascal MB 

PROVIDER: S-EPMC9162156 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature