A scoping review of randomized trials assessing the impact of n-of-1 trials on clinical outcomes.

ABSTRACT:

Background

The single patient (n-of-1) trial can be used to resolve therapeutic uncertainty for the individual patient. Treatment alternatives are systematically tested against each other, generating patient-specific data used to inform an individualized treatment plan. We hypothesize that clinical decisions informed by n-of-1 trials improve patient outcomes compared to usual care. Our objective was to provide an overview of the clinical trial evidence on the effect of n-of-1 trials on clinical outcomes.

Methods

A systematic search of medical databases, trial registries, and gray literature was performed to identify trials assessing clinical outcomes in a group of patients undergoing an n-of-1 trial compared to those receiving usual care for any clinical condition. We abstra

SUBMITTER: Samuel JP 

PROVIDER: S-EPMC9162303 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature