A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program.

ABSTRACT:

Background

Height has been associated with many clinical traits but whether such associations are causal versus secondary to confounding remains unclear in many cases. To systematically examine this question, we performed a Mendelian Randomization-Phenome-wide association study (MR-PheWAS) using clinical and genetic data from a national healthcare system biobank.

Methods and findings

Analyses were performed using data from the US Veterans Affairs (VA) Million Veteran Program in non-Hispanic White (EA, n = 222,300) and non-Hispanic Black (AA, n = 58,151) adults in the US. We estimated height genetic risk based on 3290 height-associated variants from a recent European-ancestry genome-wide meta-analysis. We compared associations of measured and genetically-predicted height with

SUBMITTER: Raghavan S 

PROVIDER: S-EPMC9162317 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature