Genetic association of ANRIL with susceptibility to Ischemic stroke: A comprehensive meta-analysis.

ABSTRACT:

Background

Ischemic stroke (IS) is a complex polygenic disease with a strong genetic background. The relationship between the ANRIL (antisense non-coding RNA in the INK4 locus) in chromosome 9p21 region and IS has been reported across populations worldwide; however, these studies have yielded inconsistent results. The aim of this study is to clarify the types of single-nucleotide polymorphisms on the ANRIL locus associated with susceptibility to IS using meta-analysis and comprehensively assess the strength of the association.

Methods

Relevant studies were identified by comprehensive and systematic literature searches. The quality of each study was assessed using the Newcastle-Ottawa Scale. Allele and genotype frequencies were extracted from each of the included studies. Odd

SUBMITTER: Bai N 

PROVIDER: S-EPMC9162336 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature