A juxtamembrane basolateral targeting motif regulates signaling through a TGF-β pathway receptor in Drosophila.

ABSTRACT: In polarized epithelial cells, receptor-ligand interactions can be restricted by different spatial distributions of the 2 interacting components, giving rise to an underappreciated layer of regulatory complexity. We explored whether such regulation occurs in the Drosophila wing disc, an epithelial tissue featuring the TGF-β family member Decapentaplegic (Dpp) as a morphogen controlling growth and patterning. Dpp protein has been observed in an extracellular gradient within the columnar cell layer of the disc, but also uniformly in the disc lumen, leading to the question of how graded signaling is achieved in the face of 2 distinctly localized ligand pools. We find the Dpp Type II receptor Punt, but not the Type I receptor Tkv, is enriched at the basolateral membrane and depleted at the jun

SUBMITTER: Peterson AJ 

PROVIDER: S-EPMC9162340 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature