Levodopa ONOFF-state freezing of gait: Defining the gait and non-motor phenotype.

ABSTRACT:

Background

Freezing in the levodopa-medicated-state (ON-state) is a debilitating feature of Parkinson's disease without treatment options. Studies detailing the distinguishing features between people with freezing of gait that improves with levodopa and those whose freezing continues even on levodopa are lacking.

Objective

To characterize the gross motor, gait, and non-motor features of this phenotype.

Methods

Instrumented continuous gait was collected in the levodopa-medicated-state in 105 patients: 43 non-freezers (no-FOG), 36 with freezing only OFF-levodopa (OFF-FOG) and 26 with freezing both ON- and OFF-levodopa (ONOFF-FOG). Evaluation of motor and non-motor disease features was undertaken using validated scales. A linear mixed model with age, sex, disease duratio

SUBMITTER: Landes RD 

PROVIDER: S-EPMC9162361 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature