The prognostic value of MKL1 in predicting breast cancer immune infiltrates and chemosensitivity.

ABSTRACT: Megakaryocytic leukemia 1 (MKL1) acts as a transcription factor in the regulation of the immune system and is associated with cancer biology. However, its function in the infiltrating immune cells in breast cancer has not been explored. Our study aimed to analyze the expression of MKL1 in The Cancer Genome Atlas (TCGA) breast cancer dataset. The aim of this study was to evaluate the correlations between MKL1 expression, infiltrating immune cells, and immune control genes. Enriched signaling pathways and drug sensitivity analyses were also performed. Our results indicate that high MKL1 expression could predict better survival in breast cancer patients. MKL1 expression was associated with the expression and function of different immune cells, including T cells, B cells, natural killer (NK) c

SUBMITTER: Hua Y 

PROVIDER: S-EPMC9162751 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature