Genome-wide characterization of RNA editing highlights roles of high editing events of glutamatergic synapse during mouse retinal development.

ABSTRACT: Adenosine-to-inosine (A-to-I) RNA editing leads to functional change of neurotransmitter receptor which is essential for neurotransmission and normal neuronal development. As a highly accessible part of central nervous system, retina has been extensively studied, however, it remains largely unknown how RNA editing regulates its development. Here, a genome-wide screening of high-confidence RNA editing events were performed to decipher the dynamic transcriptome regulation by RNA editing during mouse retinal development. 2000 high-confidence editing sites across eight developmental stages of retina were called. Three unique patterns (RNA-editing^high pattern, RNA-editing^medium pattern and RNA-editing^low pattern) were identified by clustering these editing sites

SUBMITTER: Li C 

PROVIDER: S-EPMC9162912 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature