Study on the development and integration of 3D-printed optics in small-scale productions of single-use cultivation vessels.

ABSTRACT: Integrating optical sensors and 3D-printed optics into single-use (SU) cultivation vessels for customized, tailor-made equipment could be a next big step in the bioreactor and screening platform development enabling online bioprocess monitoring. Many different parameters such as pH, oxygen, carbon dioxide and optical density (OD) can be monitored more easily using online measuring instruments compared to offline sampling. Space-saving integrated sensors in combination with adapted optics such as prisms open up vastly new possibilities to precisely guide light through SU vessels. This study examines how optical prisms can be 3D-printed with a 3D-inkjet printer, modified and then evaluated in a custom made optical bench. The prisms are coated or bonded with thin cover glasses. For the examin

SUBMITTER: Kuhnke LM 

PROVIDER: S-EPMC9162927 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature