Development of an automated closed-loop β-blocker delivery system to stably reduce myocardial oxygen consumption without inducing circulatory collapse in a canine heart failure model: a proof of concept study.

ABSTRACT: Beta-blockers are well known to reduce myocardial oxygen consumption (MVO₂) and improve the prognosis of heart failure (HF) patients. However, its negative chronotropic and inotropic effects limit their use in the acute phase of HF due to the risk of circulatory collapse. In this study, as a first step for a safe β-blocker administration strategy, we aimed to develop and evaluate the feasibility of an automated β-blocker administration system. We developed a system to monitor arterial pressure (AP), left atrial pressure (P_LA), right atrial pressure, and cardiac output. Using negative feedback of hemodynamics, the system controls AP and P_LA by administering landiolol (an ultra-short-acting β-blocker), dextran, and furosemide. We applied the system for 60 min

SUBMITTER: Nishikawa T 

PROVIDER: S-EPMC9162998 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature