T-cell immune response predicts the risk of critical SARS-Cov2 infection in hospitalized COVID-19 patients.

ABSTRACT:

Introduction

This study aimed to identify markers of disease worsening in patients hospitalized for SARS-Cov2 infection.

Patients and methods

Patients hospitalized for severe recent-onset (<1 week) SARS-Cov2 infection were prospectively included. The percentage of T-cell subsets and plasma IL-6 at admission (before any steroid therapy) were compared between patients who progressed to a critical infection and those who did not.

Results

Thirty-seven patients (18 men, 19 women) were included; 11 (30%) progressed to critical infection. At admission, the critical infection patients were older (P = 0.021), had higher creatinine levels (P = 0.003), and decreased percentages of circulating B cells (P = 0.04), T cells (P = 0.009), and CD4+ T cells (P = 0.004) than those with a

SUBMITTER: Samson M 

PROVIDER: S-EPMC9163020 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature