Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate.

ABSTRACT: The formation of membraneless organelles can be a proteotoxic stress control mechanism that locally condenses a set of components capable of mediating protein degradation decisions. The breadth of mechanisms by which cells respond to stressors and form specific functional types of membraneless organelles, is incompletely understood. We found that Bcl2-associated athanogene 2 (BAG2) marks a distinct phase-separated membraneless organelle, triggered by several forms of stress, particularly hyper-osmotic stress. Distinct from well-known condensates such as stress granules and processing bodies, BAG2-containing granules lack RNA, lack ubiquitin and promote client degradation in a ubiquitin-independent manner via the 20S proteasome. These organelles protect the viability of cells from stress an

SUBMITTER: Carrettiero DC 

PROVIDER: S-EPMC9163039 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature