HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function.

ABSTRACT: Clinical cancer genome sequencing detects oncogenic variants that are potential targets for cancer treatment, but it also detects variants of unknown significance. These variants may interact with each other to influence tumor pathophysiology, however, such interactions have not been fully elucidated. Additionally, the effect of target therapy for those variants also unclarified. In this study, we investigated the biological functions of a HER2 mutation (G776S mutation) of unknown pathological significance, which was detected together with APC mutation by cancer genome sequencing of samples from a colorectal cancer (CRC) patient. Transfection of the HER2 G776S mutation alone slightly increased the kinase activity and phosphorylation of HER2 protein, but did not activate HER2 downstream sig

SUBMITTER: Mitani Y 

PROVIDER: S-EPMC9163061 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature