Effect of PET-CT misalignment on the quantitative accuracy of cardiac ¹⁵O-water PET.

ABSTRACT:

Background

Quantification of myocardial blood flow (MBF) with PET requires accurate attenuation correction, which is performed using a separate CT. Misalignment between PET and CT scans has been reported to be a common problem. The purpose of the present study was to assess the effect of PET CT misalignment on the quantitative accuracy of cardiac ¹⁵O-water PET.

Methods

Ten clinical patients referred for evaluation of ischemia and assessment of MBF with ¹⁵O-water were included in the study. Eleven different misalignments between PET and CT were induced in 6 different directions with 10 and 20 mm amplitudes: caudal (+Z), cranial (- Z), lateral (±X), anterior (+Y), and anterior combined with cranial (+ Y and - Z). Blood flow was quantified from rates of wa

SUBMITTER: Nordstrom J 

PROVIDER: S-EPMC9163113 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature