Changes in adiponectin:leptin ratio among older adults with obesity following a 12-month exercise and diet intervention.

ABSTRACT:

Background

Excess adiposity is characterized by alterations in adipokine secretion such that circulating leptin concentrations are increased with reductions in adiponectin. An emerging biomarker for the assessment of this adipose tissue (AT) dysfunction is the adiponectin:leptin (AL) ratio. A low AL ratio may be suggestive of dysfunctional AT and, consequently, a heightened cardiometabolic disease risk. This ancillary study investigated the relationship between the AL ratio and cardiometabolic health among community-dwelling older adults with obesity, as well as the effects of a 12-month exercise and diet intervention on changes in the AL ratio.

Methods

Participants (n = 163, 70.2 ± 4.7 years, 38.0% male) were randomized to the exercise only group, exercise + nutrient-dense

SUBMITTER: Senkus KE 

PROVIDER: S-EPMC9163185 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature