Metabolomic Profiling for Histologically Fibrotic Stage in Chronic Drug-Induced Liver Injury.

ABSTRACT: Background and aims: Chronic drug-induced liver injury (DILI) is a rare but under-researched adverse drug reaction-related disease, which is highly likely to progress into liver fibrosis and even cirrhosis. In this study, metabolomics was used to screen out characteristic metabolites related to the histological progression of fibrosis in chronic DILI and analyze the metabolic changes during the development of fibrosis to explain the underlying mechanism. Methods: Chronic DILI patients who underwent liver biopsy were divided into different fibrosis grades. Serum was analyzed by untargeted metabolomics to find serological characteristic metabolite fingerprints. The screened fingerprints were validated by the validation group patients, and the identification ability of fingerpri

SUBMITTER: He X 

PROVIDER: S-EPMC9163384 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature