Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration.

ABSTRACT: Osteochondral defects (OCD) cannot be efficiently repaired due to the unique physical architecture and the pathological microenvironment including enhanced oxidative stress and inflammation. Conventional strategies, such as the control of implant microstructure or the introduction of growth factors, have limited functions failing to manage these complex environments. Here we developed a multifunctional silk-based hydrogel incorporated with metal-organic framework nanozymes (CuTA@SF) to provide a suitable microenvironment for enhanced OCD regeneration. The incorporation of CuTA nanozymes endowed the SF hydrogel with a uniform microstructure and elevated hydrophilicity. In vitro cultivation of mesenchymal stem cells (MSCs) and chondrocytes showed that CuTA@SF hydrogel accelerated cell prolif

SUBMITTER: Cao Z 

PROVIDER: S-EPMC9163388 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature