Genetic Variants Associated With Resilience in Human and Animal Studies.

ABSTRACT: Resilience is broadly defined as the ability to maintain or regain functioning in the face of adversity and is influenced by both environmental and genetic factors. The identification of specific genetic factors and their biological pathways underpinning resilient functioning can help in the identification of common key factors, but heterogeneities in the operationalisation of resilience have hampered advances. We conducted a systematic review of genetic variants associated with resilience to enable the identification of general resilience mechanisms. We adopted broad inclusion criteria for the definition of resilience to capture both human and animal model studies, which use a wide range of resilience definitions and measure very different outcomes. Analyzing 158 studies, we found 71 cand

SUBMITTER: Cahill S 

PROVIDER: S-EPMC9163442 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature