Systematic review of donor and recipient predictive biomarkers of response to faecal microbiota transplantation in patients with ulcerative colitis.

ABSTRACT:

Background

Faecal microbiota transplantation (FMT) has previously been explored as a treatment for ulcerative colitis (UC) however, biomarkers that predict and / or are associated with clinical response are poorly defined. The aim of this systematic review was to identify donor and recipient clinical, microbial and metabolomic predictive biomarkers of response to FMT in UC.

Methods

A systematic search of the relevant literature of studies exploring FMT in UC was conducted. Data on microbial diversity, taxonomic changes, metabolic changes, donor and recipient microbiota relationship and baseline predictors was examined.

Findings

2852 studies were screened, and 25 papers were included in this systematic review. Following FMT, alpha diversity was seen to increase in resp

SUBMITTER: Rees NP 

PROVIDER: S-EPMC9163485 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature