Associations Between Disordered Microbial Metabolites and Changes of Neurotransmitters in Depressed Mice.

ABSTRACT:

Backgrounds

Many pieces of evidence demonstrated that there were close relationships between gut microbiota and depression. However, the specific molecular mechanisms were still unknown. Here, using targeted metabolomics, this study was conducted to explore the relationships between microbial metabolites in feces and neurotransmitters in prefrontal cortex of depressed mice.

Methods

Chronic unpredictable mild stress (CUMS) model of depression was built in this study. Targeted liquid chromatography-mass spectrometry analysis was used to detect the microbial metabolites in feces and neurotransmitters in prefrontal cortex of mice. Both univariate and multivariate statistical analyses were applied to identify the differential microbial metabolites and neurotransmitters and explor

SUBMITTER: Xie J 

PROVIDER: S-EPMC9163491 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature