Revisiting differences between atopic and non-atopic asthmatics: When age is shaping airway inflammatory profile.

ABSTRACT:

Background

Atopic asthma is one of the most common asthma phenotypes and is generally opposed to the non-atopic counterpart. There have been very few large-scale studies comparing atopic and non-atopic asthmatics in terms of systemic and airway inflammation across the age spectrum.

Methods

Here, we have undertaken a retrospective study investigating 1626 patients (924 atopic and 702 non-atopic asthmatics) recruited from our university asthma clinic who underwent extensive clinical investigations including induced sputum. Atopy was defined by any positive specific IgE to common aeroallergens (>0,35 kU/L). We performed direct comparisons between the groups and sought to appreciate the influence of age on the airway and systemic inflammatory components. The study was approved b

SUBMITTER: Gerday S 

PROVIDER: S-EPMC9163576 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature