Magnetic susceptibility anisotropy in normal appearing white matter in multiple sclerosis from single-orientation acquisition.

ABSTRACT: Quantitative susceptibility mapping (QSM) has been successfully applied to study changes in deep grey matter nuclei as well as in lesional tissue, but its application to white matter has been complicated by the observed orientation dependence of gradient echo signal. The anisotropic susceptibility tensor is thought to be at the origin of this orientation dependence, and magnetic susceptibility anisotropy (MSA) derived from this tensor has been proposed as a marker of the state and integrity of the myelin sheath and may therefore be of particular interest for the study of demyelinating pathologies such as multiple sclerosis (MS). Reconstruction of the susceptibility tensor, however, requires repeated measurements with multiple head orientations, rendering the approach impractical for clinic

SUBMITTER: Sibgatulin R 

PROVIDER: S-EPMC9163587 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature